IMMUNE SYSTEM & NK CELL

IMMUNE SYSTEM & NK CELL

What is the immune system?

IMMUNE SYSTEM & NK CELL

Immune system (IMMUNE SYSTEM) is a natural defensive system created by the body structure through biological processes such as tissue cells, organs and molecules. The immune system acts to prevent and resist various diseases, if it is powerful, chance of getting affected by various diseases will be decreasing.

Types of immune systems

  1. Innate immunity, such as NK cells (natural killer cells, which are components of the innate immune system from the bone marrow, considered as one of white blood cell)
  2. Adaptive immunity, consists of…
    • Active immunity, it is created after the body receives antigens or specific weak pathogens of a disease, for instance, vaccines used to protect that specific disease.
    • Passive immunity is an immunity derived from blood of living thing provided by injecting it to the body in order to resist spread of disease immediately such as, serum that used to cure snake poison, rabies, tetanus, diphtheria and breast milk.

The importance of immunity

When the immune system works well, it is like having a strong army team that can be able to protect the body from the invasion of various germs such as, bacteria, viruses, or germs. Each of them has different sizes. For example, a small size of it like virus that our body can easily attack. However, if the size is big (tumor) then it is essential to have more numbers of strong immunity to fight against it. The body immunity that has both, good amount and quality, the attack from infection, cancer and other diseases will be stopped, therefore, your body will go back to its normal condition. In addition, the word “germ” means everything that causes you infection or disease.


NK CELLS Function

IMMUNE SYSTEM & NK CELL

Army team of the non-specific immune system in the body include NK Cells (Natural Killer Cells) considered as a type of white blood cell, known as “Lymphocyte”. Moreover, this cell is a key component of the immune system compared as a frontier that fights against dangerous foreign cells.



TCELS – เซลล์บำบัด รักษามะเร็งเม็ดเลือดขาว ขอบคุณข้อมูลจาก : คณะแพทย์ศาสตร์จุฬาลงกรณ์มหาวิทยาลัย



Normally, the body contains about two thousand million to five thousand million of NK Cells, when the foreign cells invade in the body, the cells can immediately detect it and fight the harmful cells within 24 hours. As a result, these following reactions will be showing:

  1. NK Cells will deal with foreign cells by creating a chain reaction which directly kills the foreign cells called “Cytotoxicity”
  2. NK Cells will work along with releasing protein into the bloodstream called “Cytokine” that responds by calling other cells in the immune system to come help the NK Cells kill foreign cells such as, preventing the growth of tumor.




How does the NK Cells Activity Work?

The efficiency of NK Cells capability called “NK Cell Activity” is a measurement of ability whether the body can fight the harmful foreign cells effectively or not, including helping a doctor evaluate the strength of the immune system for this prevention.


IMMUNE SYSTEM & NK CELL

NK Cell Activity is a value that reflects number of factors or diseases in people individually, for example, high stress, insomnia or improper nutrition. Those with low NK Cell Activity value may have indication of high risk for diseases, which could be any infection. However, even it cannot define an exact disease that maybe a person is having but, the value supports doctor’s decision for providing additional screening in case if the person has a condition of health or any specific disease.

Level of NK Cells Activity Measurement

IMMUNE SYSTEM & NK CELL
IMMUNE SYSTEM & NK CELL

Immunity NK Test is the first technology that helps measuring amounts of IFN-gramma, this value helps assess capacity of the non-specific innate immune system that defines an ability to prevent the body from virus infection and fight against cancer cells. The measuring accredited by The MFDS (Ministry of Food and Drug Safety) October, 2012 (12-1357) and Novel Health Technology after being approved by NECA (National Evidence-based healthcare Collaborating Agency) June, 2014.


Who should receive NK Cells Activity Screening?

  • Healthy people who would to check up their innate immune function.
  • People with frequent infections.
  • People who have been exposed to hormones or pollution directly for a long time.
  • People with chronic fatigue symptom.
  • People with a history of heavy smoking.
  • People who have family members with a history of having cancer.

Increase power of your immunity by NK Cell Therapy

IMMUNE SYSTEM & NK CELL

For those with an indication of low NK Cell Activity, which is below its normal value (100-250), the function of the NK Cells may relate to health- conditions or sign of disease during its early stages. Therefore, they should improve and enhance their own immunity.


Furthermore, although the indication of NK Cell Activity remains normal (250-500), that person still requires well-care of the immunity. The doctor will analyze the value together with health check-up to provide a proper suggestion for patients to boost their immunity individually such as taking mediation or keeping the immunity cells (Active NK Cells + lymphocytes) from their blood so that it can used for boosting the immunity in the future or suddenly.






Interesting articles

Critical Review ‘NK Cell in Therapy of Cancer’

(University of Minnesota, Minneapolis, MN, USA)

NK Cell and Colon Cancer

(The Journal of Immunology, https://www.jimmunol.org)

Brief Review ‘NK cells in hepatitis B virus infection: a potent target for immunotherapy’

(Sptinger)

Review ‘NK cell-based immunotherapy for malignant diseases’

(Cellular & Molecular Immunology, 2013/10, 230–252)

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